Septins, such as SEPT13, are conserved GTP-binding proteins that function as dynamic, regulatable scaffolds for the recruitment of other proteins. They are involved in membrane dynamics, vesicle trafficking, apoptosis, and cytoskeleton remodeling, as well as infection, neurodegeneration, and neoplasia (Hall et al., 2005 [PubMed 15915442]).[supplied by OMIM, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ENSG00000291207. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000291207 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000291207, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:45,573,677–45,575,925 | 194.4 kb | Distal (>10kb) Multiome | 366 | |
| chr7:45,641,919–45,642,829 | 126.7 kb | Distal (>10kb) Multiome | 162 | |
| chr7:45,768,480–45,769,428 | 46 bp | At TSS Multiome | 528 | |
| chr7:45,888,320–45,889,503 | 119.9 kb | Distal (>10kb) Multiome | 745 | |
| chr7:45,920,336–45,922,109 | 152.0 kb | Distal (>10kb) Multiome | 377 | |
| chr7:46,015,214–46,016,175 | 246.6 kb | Distal (>10kb) Multiome | 250 | |
| chr7:47,190,020–47,191,241 | 1421.6 kb | Distal (>10kb) Multiome HiCAR | 182 |
Genomic view of the ENSG00000291207 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.