Transcription factors with Perturb-seq knockdown data for ENSG00000291186. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000291186 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000291186, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:71,607,766–71,608,303 | 179.6 kb | Distal (>10kb) Multiome | 13 | |
| chr11:71,786,388–71,787,283 | 433 bp | At TSS Multiome | 289 | |
| chr11:71,928,161–71,929,328 | 141.3 kb | Distal (>10kb) Multiome | 869 | |
| chr11:72,040,697–72,041,585 | 253.5 kb | Distal (>10kb) Multiome | 586 | |
| chr11:72,080,144–72,081,188 | 293.2 kb | Distal (>10kb) Multiome | 789 |
Genomic view of the ENSG00000291186 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.