Transcription factors with Perturb-seq knockdown data for ENSG00000291185. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000291185 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000291185, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:14,692,495–14,694,738 | 299.8 kb | Distal (>10kb) Multiome | 739 | |
| chr9:14,707,894–14,718,960 | 277.1 kb | Distal (>10kb) Multiome | 491 | |
| chr9:14,722,051–14,724,133 | 270.3 kb | Distal (>10kb) Multiome | 397 | |
| chr9:14,746,175–14,747,463 | 246.1 kb | Distal (>10kb) Multiome | 117 | |
| chr9:14,752,089–14,753,309 | 240.6 kb | Distal (>10kb) Multiome | 147 | |
| chr9:14,909,925–14,910,721 | 82.9 kb | Distal (>10kb) Multiome | 428 | |
| chr9:14,992,603–14,993,831 | 102 bp | At TSS Multiome | 390 | |
| chr9:15,137,894–15,138,779 | 145.2 kb | Distal (>10kb) Multiome | 126 | |
| chr9:15,249,131–15,250,215 | 256.4 kb | Distal (>10kb) Multiome | 244 |
Genomic view of the ENSG00000291185 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.