Transcription factors with Perturb-seq knockdown data for ENSG00000291147. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000291147 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000291147, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:240,818,573–240,821,401 | 1268.3 kb | Distal (>10kb) Multiome HiCAR | 419 | |
| chr2:241,843,948–241,844,465 | 244.5 kb | Distal (>10kb) Multiome | 429 | |
| chr2:241,880,851–241,882,624 | 207.0 kb | Distal (>10kb) Multiome | 665 | |
| chr2:241,950,625–241,951,263 | 137.7 kb | Distal (>10kb) Multiome | 367 | |
| chr2:242,088,158–242,089,208 | 27 bp | At TSS Multiome | 493 |
Genomic view of the ENSG00000291147 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.