Transcription factors with Perturb-seq knockdown data for ENSG00000291131. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000291131 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000291131, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:52,896,852–52,898,438 | 299.4 kb | Distal (>10kb) Multiome | 488 | |
| chr19:52,922,765–52,923,968 | 273.7 kb | Distal (>10kb) Multiome | 526 | |
| chr19:52,941,909–52,943,216 | 254.4 kb | Distal (>10kb) Multiome | 494 | |
| chr19:52,944,441–52,945,501 | 251.9 kb | Distal (>10kb) Multiome | 238 | |
| chr19:52,945,942–52,946,905 | 250.5 kb | Distal (>10kb) Multiome | 164 | |
| chr19:52,962,371–52,963,594 | 234.1 kb | Distal (>10kb) Multiome | 663 | |
| chr19:52,993,475–52,994,192 | 203.3 kb | Distal (>10kb) Multiome | 160 | |
| chr19:53,027,952–53,028,653 | 168.6 kb | Distal (>10kb) Multiome | 64 | |
| chr19:53,057,924–53,058,784 | 138.7 kb | Distal (>10kb) Multiome | 160 | |
| chr19:53,102,740–53,104,032 | 93.5 kb | Distal (>10kb) Multiome | 634 | |
| chr19:53,158,810–53,159,647 | 38.0 kb | Distal (>10kb) Multiome | 317 | |
| chr19:53,192,722–53,193,557 | 3.7 kb | Proximal (<10kb) Multiome | 285 | |
| chr19:53,195,370–53,195,581 | 1.5 kb | Proximal (<10kb) | 143 | |
| chr19:53,196,790–53,197,387 | 78 bp | At TSS Multiome | 329 | |
| chr19:53,254,450–53,255,344 | 57.8 kb | Distal (>10kb) Multiome | 295 | |
| chr19:53,333,122–53,334,368 | 136.6 kb | Distal (>10kb) Multiome | 319 | |
| chr19:53,365,124–53,366,164 | 168.5 kb | Distal (>10kb) Multiome HiCAR | 346 | |
| chr19:53,394,512–53,395,775 | 197.9 kb | Distal (>10kb) Multiome | 453 | |
| chr19:53,431,377–53,432,626 | 234.8 kb | Distal (>10kb) Multiome | 522 | |
| chr19:53,463,129–53,463,807 | 266.3 kb | Distal (>10kb) Multiome | 104 | |
| chr19:53,467,122–53,469,090 | 270.6 kb | Distal (>10kb) Multiome | 381 |
Genomic view of the ENSG00000291131 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.