Transcription factors with Perturb-seq knockdown data for ENSG00000291124. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000291124 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000291124, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:65,731,509–65,732,049 | 19.3 kb | Distal (>10kb) Multiome | 163 | |
| chr7:65,750,398–65,751,615 | 76 bp | At TSS Multiome | 754 | |
| chr7:65,751,748–65,751,910 | 698 bp | At TSS | 90 | |
| chr7:65,770,451–65,770,953 | 19.7 kb | Distal (>10kb) Multiome | 335 | |
| chr7:65,872,688–65,874,131 | 122.1 kb | Distal (>10kb) Multiome | 352 | |
| chr7:65,981,748–65,982,750 | 231.2 kb | Distal (>10kb) Multiome | 996 | |
| chr7:66,043,712–66,044,711 | 293.3 kb | Distal (>10kb) Multiome | 136 |
Genomic view of the ENSG00000291124 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.