TFs regulating ENSG00000291117 0 TFs

Transcription factors with Perturb-seq knockdown data for ENSG00000291117. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000291117 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ENSG00000291117

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000291117, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:64,661,214–64,662,931	174.8 kb	Distal (>10kb) Multiome	700
chr17:64,773,965–64,774,847	62.8 kb	Distal (>10kb) Multiome	481
chr17:64,776,631–64,777,384	60.1 kb	Distal (>10kb) Multiome	616
chr17:64,778,215–64,779,097	58.4 kb	Distal (>10kb) Multiome	185
chr17:64,779,868–64,781,331	56.7 kb	Distal (>10kb) Multiome	287
chr17:64,836,863–64,837,361	3 bp	At TSS Multiome	286
chr17:64,918,788–64,920,342	82.4 kb	Distal (>10kb) Multiome	704
chr17:64,975,096–64,976,234	138.5 kb	Distal (>10kb) Multiome	1057
chr17:65,055,840–65,057,373	219.6 kb	Distal (>10kb) Multiome	946
chr17:65,057,526–65,058,894	221.2 kb	Distal (>10kb) Multiome	300
chr17:65,100,219–65,101,279	263.6 kb	Distal (>10kb) Multiome	634
chr17:65,123,077–65,123,614	286.2 kb	Distal (>10kb) Multiome	724
chr17:65,136,968–65,137,867	300.1 kb	Distal (>10kb) Multiome	573

Genome Browser

Genomic view of the ENSG00000291117 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.