Transcription factors with Perturb-seq knockdown data for ENSG00000291113. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000291113 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000291113, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:177,516,515–177,517,551 | 292.4 kb | Distal (>10kb) Multiome | 958 | |
| chr5:177,553,719–177,554,931 | 254.9 kb | Distal (>10kb) Multiome | 671 | |
| chr5:177,591,993–177,592,765 | 217.2 kb | Distal (>10kb) Multiome | 724 | |
| chr5:177,599,409–177,600,500 | 209.4 kb | Distal (>10kb) Multiome | 871 | |
| chr5:177,607,310–177,608,120 | 201.8 kb | Distal (>10kb) Multiome | 392 | |
| chr5:178,075,958–178,076,432 | 266.8 kb | Distal (>10kb) Multiome | 336 |
Genomic view of the ENSG00000291113 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.