Transcription factors with Perturb-seq knockdown data for ENSG00000291099. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000291099 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000291099, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:5,524,684–5,527,073 | 296.5 kb | Distal (>10kb) Multiome | 736 | |
| chr7:5,529,088–5,532,313 | 293.2 kb | Distal (>10kb) Multiome | 1081 | |
| chr7:5,554,765–5,555,676 | 267.9 kb | Distal (>10kb) Multiome | 643 | |
| chr7:5,555,801–5,557,053 | 266.5 kb | Distal (>10kb) Multiome | 807 | |
| chr7:5,558,744–5,559,347 | 264.1 kb | Distal (>10kb) Multiome | 525 | |
| chr7:5,562,000–5,564,024 | 261.1 kb | Distal (>10kb) Multiome | 859 | |
| chr7:5,569,367–5,570,943 | 252.9 kb | Distal (>10kb) Multiome | 694 | |
| chr7:5,574,238–5,575,433 | 248.2 kb | Distal (>10kb) Multiome | 447 | |
| chr7:5,591,580–5,596,769 | 230.4 kb | Distal (>10kb) Multiome | 1056 | |
| chr7:5,606,973–5,608,439 | 215.5 kb | Distal (>10kb) Multiome | 322 | |
| chr7:5,781,073–5,781,919 | 41.5 kb | Distal (>10kb) Multiome | 696 | |
| chr7:5,822,727–5,823,386 | 64 bp | At TSS Multiome | 650 | |
| chr7:6,008,669–6,009,907 | 186.1 kb | Distal (>10kb) Multiome | 1068 | |
| chr7:6,058,614–6,059,749 | 236.0 kb | Distal (>10kb) Multiome | 916 | |
| chr7:6,081,109–6,081,851 | 258.4 kb | Distal (>10kb) Multiome | 904 | |
| chr7:6,103,982–6,105,662 | 281.6 kb | Distal (>10kb) Multiome | 1040 |
Genomic view of the ENSG00000291099 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.