Transcription factors with Perturb-seq knockdown data for ENSG00000291060. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000291060 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000291060, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:21,277,829–21,278,645 | 1158.8 kb | Distal (>10kb) Multiome HiCAR | 636 | |
| chr16:21,300,604–21,301,993 | 1136.3 kb | Distal (>10kb) Multiome HiCAR | 1062 | |
| chr16:21,302,514–21,303,208 | 1134.2 kb | Distal (>10kb) Multiome HiCAR | 136 | |
| chr16:21,501,368–21,502,964 | 934.7 kb | Distal (>10kb) Multiome HiCAR | 766 | |
| chr16:21,519,749–21,521,002 | 916.6 kb | Distal (>10kb) Multiome HiCAR | 859 | |
| chr16:21,521,389–21,522,043 | 915.3 kb | Distal (>10kb) Multiome HiCAR | 479 | |
| chr16:22,189,506–22,191,692 | 246.2 kb | Distal (>10kb) Multiome | 989 | |
| chr16:22,195,474–22,196,347 | 241.2 kb | Distal (>10kb) Multiome | 886 | |
| chr16:22,205,924–22,206,847 | 230.8 kb | Distal (>10kb) Multiome | 1038 | |
| chr16:22,296,790–22,298,718 | 138.4 kb | Distal (>10kb) Multiome | 1288 | |
| chr16:22,373,797–22,375,383 | 62.3 kb | Distal (>10kb) Multiome | 951 | |
| chr16:22,436,881–22,437,622 | 64 bp | At TSS Multiome | 642 | |
| chr16:22,634,974–22,635,717 | 198.3 kb | Distal (>10kb) Multiome | 127 | |
| chr16:22,727,898–22,728,946 | 291.3 kb | Distal (>10kb) Multiome | 321 |
Genomic view of the ENSG00000291060 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.