Transcription factors with Perturb-seq knockdown data for ENSG00000291046. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000291046 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000291046, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:21,060,253–21,061,988 | 236.5 kb | Distal (>10kb) Multiome | 817 | |
| chr13:21,075,367–21,076,193 | 222.3 kb | Distal (>10kb) Multiome | 151 | |
| chr13:21,139,877–21,141,067 | 157.6 kb | Distal (>10kb) Multiome | 784 | |
| chr13:21,176,109–21,177,241 | 121.5 kb | Distal (>10kb) Multiome | 933 | |
| chr13:21,297,062–21,297,463 | 667 bp | At TSS | 74 | |
| chr13:21,297,571–21,297,796 | 334 bp | At TSS | 65 | |
| chr13:21,297,800–21,298,863 | 97 bp | At TSS Multiome | 776 | |
| chr13:21,306,303–21,306,952 | 8.2 kb | Proximal (<10kb) | 70 | |
| chr13:21,323,603–21,323,835 | 2.4 kb | Proximal (<10kb) | 6 | |
| chr13:21,326,200–21,327,030 | 28.5 kb | Distal (>10kb) Multiome | 179 | |
| chr13:21,410,303–21,410,800 | 112.5 kb | Distal (>10kb) Multiome | 76 | |
| chr13:21,458,471–21,459,892 | 161.3 kb | Distal (>10kb) Multiome | 682 | |
| chr13:21,603,478–21,604,537 | 305.9 kb | Distal (>10kb) Multiome | 918 |
Genomic view of the ENSG00000291046 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.