Transcription factors with Perturb-seq knockdown data for ENSG00000290995. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000290995 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000290995, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:67,757,971–67,758,804 | 197.5 kb | Distal (>10kb) Multiome | 61 | |
| chr11:67,804,576–67,806,617 | 150.1 kb | Distal (>10kb) Multiome | 372 | |
| chr11:67,955,492–67,956,004 | 13 bp | At TSS Multiome | 140 | |
| chr11:67,996,583–67,997,678 | 41.2 kb | Distal (>10kb) Multiome | 394 | |
| chr11:68,002,991–68,004,268 | 48.2 kb | Distal (>10kb) Multiome | 634 | |
| chr11:68,030,139–68,031,153 | 74.8 kb | Distal (>10kb) Multiome | 708 | |
| chr11:68,038,378–68,039,498 | 83.1 kb | Distal (>10kb) Multiome | 819 | |
| chr11:68,120,465–68,122,314 | 165.7 kb | Distal (>10kb) Multiome | 921 | |
| chr11:68,127,759–68,129,017 | 172.7 kb | Distal (>10kb) Multiome | 604 | |
| chr11:68,212,619–68,214,642 | 257.1 kb | Distal (>10kb) Multiome | 967 |
Genomic view of the ENSG00000290995 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.