Transcription factors with Perturb-seq knockdown data for ENSG00000290957. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000290957 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000290957, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:16,737,938–16,739,159 | 275.8 kb | Distal (>10kb) Multiome | 894 | |
| chr11:16,924,840–16,926,923 | 88.5 kb | Distal (>10kb) Multiome | 568 | |
| chr11:16,986,876–16,987,479 | 27.1 kb | Distal (>10kb) Multiome | 258 | |
| chr11:17,013,111–17,015,356 | 745 bp | At TSS Multiome | 708 | |
| chr11:17,077,236–17,078,393 | 63.5 kb | Distal (>10kb) Multiome | 940 | |
| chr11:17,207,430–17,209,576 | 193.8 kb | Distal (>10kb) Multiome | 1006 | |
| chr11:17,276,170–17,277,311 | 262.4 kb | Distal (>10kb) Multiome | 866 |
Genomic view of the ENSG00000290957 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.