Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ENSG00000290951. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000290951 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000290951, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:75,073,093–75,074,178 | 285.4 kb | Distal (>10kb) Multiome | 785 | |
| chr7:75,156,930–75,157,393 | 202.2 kb | Distal (>10kb) Multiome | 57 | |
| chr7:75,359,130–75,359,360 | at TSS | At TSS | 36 | |
| chr7:75,486,016–75,486,644 | 127.1 kb | Distal (>10kb) Multiome | 434 | |
| chr7:75,527,536–75,528,568 | 168.9 kb | Distal (>10kb) Multiome | 667 | |
| chr7:75,531,374–75,531,886 | 172.4 kb | Distal (>10kb) Multiome | 161 | |
| chr7:75,546,305–75,547,063 | 187.3 kb | Distal (>10kb) Multiome | 150 | |
| chr7:75,638,467–75,640,092 | 280.4 kb | Distal (>10kb) Multiome | 654 |
Genomic view of the ENSG00000290951 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.