Transcription factors with Perturb-seq knockdown data for ENSG00000290948. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000290948 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000290948, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:82,262,203–82,263,651 | 251.2 kb | Distal (>10kb) Multiome | 696 | |
| chr15:82,571,710–82,572,201 | 57.9 kb | Distal (>10kb) Multiome | 194 | |
| chr15:82,647,462–82,648,736 | 134.2 kb | Distal (>10kb) Multiome | 511 | |
| chr15:82,679,753–82,681,281 | 166.6 kb | Distal (>10kb) Multiome | 495 | |
| chr15:82,708,766–82,710,416 | 195.7 kb | Distal (>10kb) Multiome | 725 | |
| chr15:82,750,200–82,750,777 | 236.6 kb | Distal (>10kb) Multiome | 790 | |
| chr15:82,809,212–82,810,601 | 295.7 kb | Distal (>10kb) Multiome | 808 |
Genomic view of the ENSG00000290948 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.