Transcription factors with Perturb-seq knockdown data for ENSG00000290829. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000290829 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000290829, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:11,736,329–11,736,895 | 278.7 kb | Distal (>10kb) Multiome | 615 | |
| chr8:11,769,172–11,770,442 | 245.5 kb | Distal (>10kb) Multiome | 764 | |
| chr8:11,801,766–11,803,423 | 212.6 kb | Distal (>10kb) Multiome | 901 | |
| chr8:11,807,986–11,809,046 | 206.8 kb | Distal (>10kb) Multiome | 514 | |
| chr8:11,867,298–11,868,997 | 147.0 kb | Distal (>10kb) Multiome | 752 | |
| chr8:11,902,256–11,902,767 | 112.7 kb | Distal (>10kb) Multiome | 604 | |
| chr8:11,986,166–11,987,022 | 28.6 kb | Distal (>10kb) Multiome | 233 |
Genomic view of the ENSG00000290829 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.