Transcription factors with Perturb-seq knockdown data for ENSG00000290796. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000290796 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000290796, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:25,110,786–25,111,782 | 294.2 kb | Distal (>10kb) Multiome | 660 | |
| chr22:25,282,558–25,283,192 | 122.6 kb | Distal (>10kb) Multiome | 166 | |
| chr22:25,404,701–25,405,580 | 122 bp | At TSS Multiome | 401 | |
| chr22:25,447,876–25,448,332 | 42.6 kb | Distal (>10kb) Multiome | 586 | |
| chr22:25,564,100–25,565,570 | 159.4 kb | Distal (>10kb) Multiome | 530 |
Genomic view of the ENSG00000290796 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.