Transcription factors with Perturb-seq knockdown data for ENSG00000290576. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000290576 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000290576, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:98,593,166–98,594,492 | 1606.2 kb | Distal (>10kb) Multiome HiCAR | 874 | |
| chr12:99,983,831–99,985,388 | 215.0 kb | Distal (>10kb) Multiome | 468 | |
| chr12:100,141,965–100,143,502 | 56.9 kb | Distal (>10kb) Multiome | 848 | |
| chr12:100,154,424–100,155,274 | 44.9 kb | Distal (>10kb) Multiome HiCAR | 267 | |
| chr12:100,163,261–100,164,604 | 35.8 kb | Distal (>10kb) Multiome HiCAR | 445 | |
| chr12:100,199,080–100,201,296 | 1.0 kb | Proximal (<10kb) Multiome | 955 | |
| chr12:100,266,312–100,267,966 | 67.3 kb | Distal (>10kb) Multiome | 833 |
Genomic view of the ENSG00000290576 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.