Transcription factors with Perturb-seq knockdown data for ENSG00000290548. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000290548 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000290548, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:34,007,535–34,008,720 | 236.7 kb | Distal (>10kb) Multiome | 987 | |
| chr5:34,411,399–34,412,285 | 167.0 kb | Distal (>10kb) Multiome | 313 | |
| chr5:34,474,588–34,475,820 | 230.6 kb | Distal (>10kb) Multiome | 304 | |
| chr5:34,523,029–34,523,610 | 278.4 kb | Distal (>10kb) Multiome | 321 |
Genomic view of the ENSG00000290548 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.