Transcription factors with Perturb-seq knockdown data for ENSG00000290453. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000290453 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000290453, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:46,540,658–46,543,680 | 1010.6 kb | Distal (>10kb) Multiome HiCAR | 351 | |
| chr10:46,555,197–46,559,190 | 995.6 kb | Distal (>10kb) Multiome HiCAR | 519 | |
| chr10:47,299,907–47,300,920 | 251.6 kb | Distal (>10kb) Multiome | 218 | |
| chr10:47,383,679–47,384,935 | 167.5 kb | Distal (>10kb) Multiome | 621 | |
| chr10:47,553,175–47,553,705 | 1.5 kb | Proximal (<10kb) Multiome | 425 |
Genomic view of the ENSG00000290453 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.