Transcription factors with Perturb-seq knockdown data for ENSG00000290106. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000290106 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000290106, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:25,851,509–25,852,065 | 3.3 kb | Proximal (<10kb) | 260 | |
| chr7:25,852,154–25,853,101 | 2.2 kb | Proximal (<10kb) | 265 | |
| chr7:25,854,641–25,855,390 | at TSS | At TSS | 404 | |
| chr7:25,856,491–25,858,198 | 1.2 kb | Proximal (<10kb) | 687 | |
| chr7:25,858,937–25,859,166 | 3.6 kb | Proximal (<10kb) | 121 | |
| chr7:25,861,814–25,863,111 | 6.5 kb | Proximal (<10kb) | 616 |
Genomic view of the ENSG00000290106 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.