Transcription factors with Perturb-seq knockdown data for ENSG00000290057. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000290057 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000290057, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:65,416,383–65,417,015 | 4.4 kb | Proximal (<10kb) | 664 | |
| chr11:65,417,855–65,419,687 | 1.8 kb | Proximal (<10kb) | 1018 | |
| chr11:65,421,243–65,421,721 | at TSS | At TSS | 747 | |
| chr11:65,421,858–65,423,533 | 411 bp | At TSS | 1197 | |
| chr11:65,425,230–65,425,666 | 3.8 kb | Proximal (<10kb) | 440 |
Genomic view of the ENSG00000290057 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.