Transcription factors with Perturb-seq knockdown data for ENSG00000290008. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000290008 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000290008, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:15,073,077–15,073,718 | 259.2 kb | Distal (>10kb) Multiome | 204 | |
| chr19:15,106,942–15,107,576 | 225.3 kb | Distal (>10kb) Multiome | 339 | |
| chr19:15,113,323–15,113,828 | 219.0 kb | Distal (>10kb) Multiome | 116 | |
| chr19:15,124,546–15,126,107 | 206.9 kb | Distal (>10kb) Multiome | 949 | |
| chr19:15,177,520–15,178,026 | 154.9 kb | Distal (>10kb) Multiome | 499 | |
| chr19:15,180,886–15,181,623 | 151.4 kb | Distal (>10kb) Multiome | 355 | |
| chr19:15,195,187–15,196,375 | 136.5 kb | Distal (>10kb) Multiome | 408 | |
| chr19:15,199,629–15,201,437 | 132.5 kb | Distal (>10kb) Multiome | 398 | |
| chr19:15,222,727–15,224,168 | 109.1 kb | Distal (>10kb) Multiome | 521 | |
| chr19:15,231,632–15,233,858 | 99.4 kb | Distal (>10kb) Multiome | 414 | |
| chr19:15,324,741–15,325,392 | 7.7 kb | Proximal (<10kb) Multiome | 183 | |
| chr19:15,329,987–15,330,443 | 2.2 kb | Proximal (<10kb) | 115 | |
| chr19:15,331,471–15,332,992 | 74 bp | At TSS Multiome | 641 | |
| chr19:15,378,833–15,380,802 | 47.3 kb | Distal (>10kb) Multiome | 913 | |
| chr19:15,418,493–15,419,441 | 86.5 kb | Distal (>10kb) Multiome | 892 | |
| chr19:15,432,448–15,433,787 | 100.3 kb | Distal (>10kb) Multiome | 766 | |
| chr19:15,449,146–15,450,281 | 117.2 kb | Distal (>10kb) Multiome | 446 | |
| chr19:15,451,962–15,453,427 | 119.9 kb | Distal (>10kb) Multiome | 428 | |
| chr19:15,456,680–15,457,763 | 124.5 kb | Distal (>10kb) Multiome | 240 | |
| chr19:15,555,803–15,556,689 | 223.4 kb | Distal (>10kb) Multiome | 669 | |
| chr19:16,110,632–16,112,318 | 779.0 kb | Distal (>10kb) Multiome HiCAR | 866 |
Genomic view of the ENSG00000290008 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.