Transcription factors with Perturb-seq knockdown data for ENSG00000290006. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000290006 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000290006, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:26,692,203–26,693,499 | at TSS | At TSS | 974 | |
| chr1:26,695,271–26,696,473 | 2.7 kb | Proximal (<10kb) | 1053 | |
| chr1:26,696,663–26,696,983 | 4.1 kb | Proximal (<10kb) | 312 | |
| chr1:26,697,995–26,698,355 | 5.4 kb | Proximal (<10kb) | 489 |
Genomic view of the ENSG00000290006 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.