Transcription factors with Perturb-seq knockdown data for ENSG00000289985. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289985 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289985, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:11,418,061–11,419,498 | 276.4 kb | Distal (>10kb) Multiome | 421 | |
| chr19:11,420,614–11,422,979 | 272.8 kb | Distal (>10kb) Multiome | 507 | |
| chr19:11,434,817–11,436,365 | 259.7 kb | Distal (>10kb) Multiome | 927 | |
| chr19:11,479,217–11,480,146 | 215.4 kb | Distal (>10kb) Multiome | 394 | |
| chr19:11,481,847–11,483,040 | 212.8 kb | Distal (>10kb) Multiome | 938 | |
| chr19:11,504,741–11,506,612 | 189.6 kb | Distal (>10kb) Multiome | 854 | |
| chr19:11,528,581–11,529,391 | 165.9 kb | Distal (>10kb) Multiome | 866 | |
| chr19:11,535,847–11,536,353 | 158.8 kb | Distal (>10kb) Multiome | 694 | |
| chr19:11,538,464–11,539,111 | 156.2 kb | Distal (>10kb) Multiome | 235 | |
| chr19:11,539,738–11,540,434 | 154.9 kb | Distal (>10kb) Multiome | 176 | |
| chr19:11,558,908–11,559,777 | 135.7 kb | Distal (>10kb) Multiome | 686 | |
| chr19:11,597,206–11,598,107 | 97.5 kb | Distal (>10kb) Multiome | 914 | |
| chr19:11,639,337–11,640,481 | 55.2 kb | Distal (>10kb) Multiome | 660 | |
| chr19:11,694,497–11,695,341 | 64 bp | At TSS Multiome | 608 | |
| chr19:11,737,998–11,739,422 | 44.0 kb | Distal (>10kb) Multiome | 704 |
Genomic view of the ENSG00000289985 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.