Transcription factors with Perturb-seq knockdown data for ENSG00000289968. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289968 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289968, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:22,918,527–22,919,975 | 288.0 kb | Distal (>10kb) Multiome | 641 | |
| chr14:22,928,961–22,930,849 | 276.5 kb | Distal (>10kb) Multiome | 1108 | |
| chr14:22,956,530–22,957,512 | 250.2 kb | Distal (>10kb) Multiome | 983 | |
| chr14:22,981,215–22,983,249 | 224.7 kb | Distal (>10kb) Multiome | 935 | |
| chr14:23,006,674–23,007,583 | 200.2 kb | Distal (>10kb) Multiome | 1097 | |
| chr14:23,154,159–23,154,639 | 52.9 kb | Distal (>10kb) Multiome | 392 | |
| chr14:23,161,040–23,161,530 | 46.0 kb | Distal (>10kb) Multiome | 397 | |
| chr14:23,182,495–23,182,942 | 24.6 kb | Distal (>10kb) Multiome | 139 | |
| chr14:23,237,732–23,238,192 | 30.6 kb | Distal (>10kb) Multiome | 536 | |
| chr14:23,285,641–23,286,830 | 78.9 kb | Distal (>10kb) Multiome | 962 | |
| chr14:23,300,944–23,303,002 | 94.5 kb | Distal (>10kb) Multiome | 1096 | |
| chr14:23,306,324–23,307,321 | 99.5 kb | Distal (>10kb) Multiome | 871 | |
| chr14:23,320,558–23,322,196 | 113.9 kb | Distal (>10kb) Multiome | 1090 | |
| chr14:23,351,817–23,353,063 | 145.5 kb | Distal (>10kb) Multiome | 403 | |
| chr14:23,364,202–23,367,105 | 159.2 kb | Distal (>10kb) Multiome | 353 | |
| chr14:23,468,966–23,469,987 | 262.1 kb | Distal (>10kb) Multiome | 955 |
Genomic view of the ENSG00000289968 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.