Transcription factors with Perturb-seq knockdown data for ENSG00000289960. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289960 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289960, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:19,717,840–19,718,731 | 136.7 kb | Distal (>10kb) Multiome | 592 | |
| chr22:19,723,413–19,724,584 | 130.8 kb | Distal (>10kb) Multiome | 572 | |
| chr22:19,730,516–19,731,296 | 124.1 kb | Distal (>10kb) Multiome | 743 | |
| chr22:19,765,840–19,766,429 | 88.8 kb | Distal (>10kb) Multiome | 174 | |
| chr22:19,854,381–19,855,705 | 22 bp | At TSS Multiome | 1014 | |
| chr22:19,891,576–19,892,031 | 36.8 kb | Distal (>10kb) Multiome | 631 | |
| chr22:19,959,058–19,959,828 | 104.5 kb | Distal (>10kb) Multiome | 576 | |
| chr22:19,962,339–19,962,798 | 107.6 kb | Distal (>10kb) Multiome | 442 | |
| chr22:19,986,350–19,987,426 | 132.2 kb | Distal (>10kb) Multiome | 539 | |
| chr22:20,016,068–20,017,437 | 161.9 kb | Distal (>10kb) Multiome | 640 | |
| chr22:20,020,662–20,021,745 | 166.1 kb | Distal (>10kb) Multiome | 718 | |
| chr22:20,079,663–20,080,743 | 225.2 kb | Distal (>10kb) Multiome | 994 | |
| chr22:20,116,628–20,118,048 | 262.4 kb | Distal (>10kb) Multiome | 999 | |
| chr22:20,130,806–20,131,896 | 276.3 kb | Distal (>10kb) Multiome | 525 |
Genomic view of the ENSG00000289960 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.