Transcription factors with Perturb-seq knockdown data for ENSG00000289903. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289903 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289903, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:37,583,348–37,585,608 | 3.2 kb | Proximal (<10kb) | 579 | |
| chr14:37,587,658–37,588,927 | at TSS | At TSS | 732 | |
| chr14:37,591,282–37,593,025 | 2.5 kb | Proximal (<10kb) | 515 | |
| chr14:37,594,092–37,596,733 | 5.3 kb | Proximal (<10kb) | 1108 | |
| chr14:37,596,873–37,597,337 | 8.1 kb | Proximal (<10kb) | 62 | |
| chr14:37,597,595–37,599,188 | 8.8 kb | Proximal (<10kb) | 235 |
Genomic view of the ENSG00000289903 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.