Transcription factors with Perturb-seq knockdown data for ENSG00000289875. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289875 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289875, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:31,595,608–31,596,479 | 8.6 kb | Proximal (<10kb) | 676 | |
| chr20:31,604,042–31,606,325 | at TSS | At TSS | 1198 | |
| chr20:31,606,499–31,608,983 | 1.4 kb | Proximal (<10kb) | 1081 | |
| chr20:31,611,589–31,611,802 | 6.5 kb | Proximal (<10kb) | 101 | |
| chr20:31,612,623–31,613,367 | 7.5 kb | Proximal (<10kb) | 858 |
Genomic view of the ENSG00000289875 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.