Transcription factors with Perturb-seq knockdown data for ENSG00000289860. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289860 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289860, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:21,664,347–21,664,628 | 6.3 kb | Proximal (<10kb) | 14 | |
| chr13:21,669,106–21,671,240 | at TSS | At TSS | 657 | |
| chr13:21,673,391–21,674,552 | 2.4 kb | Proximal (<10kb) | 365 | |
| chr13:21,674,834–21,676,020 | 3.9 kb | Proximal (<10kb) | 258 | |
| chr13:21,676,559–21,677,162 | 5.6 kb | Proximal (<10kb) | 87 |
Genomic view of the ENSG00000289860 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.