Transcription factors with Perturb-seq knockdown data for ENSG00000289854. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289854 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289854, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:54,352,272–54,352,444 | 6.8 kb | Proximal (<10kb) | 291 | |
| chr12:54,358,197–54,358,393 | 818 bp | At TSS | 179 | |
| chr12:54,358,730–54,359,779 | at TSS | At TSS | 857 | |
| chr12:54,360,706–54,361,149 | 1.5 kb | Proximal (<10kb) | 436 | |
| chr12:54,368,741–54,368,939 | 9.5 kb | Proximal (<10kb) | 395 |
Genomic view of the ENSG00000289854 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.