Transcription factors with Perturb-seq knockdown data for ENSG00000289834. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289834 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289834, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:61,896,819–61,897,908 | 2.5 kb | Proximal (<10kb) | 530 | |
| chr10:61,898,944–61,899,278 | 1.1 kb | Proximal (<10kb) | 171 | |
| chr10:61,900,133–61,900,481 | at TSS | At TSS | 403 | |
| chr10:61,901,166–61,902,652 | 749 bp | At TSS | 519 | |
| chr10:61,902,969–61,904,116 | 2.6 kb | Proximal (<10kb) | 753 | |
| chr10:61,904,825–61,905,049 | 4.4 kb | Proximal (<10kb) | 330 |
Genomic view of the ENSG00000289834 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.