Transcription factors with Perturb-seq knockdown data for ENSG00000289826. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289826 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289826, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrY:7,272,421–7,273,090 | 1.7 kb | Proximal (<10kb) | 95 | |
| chrY:7,273,462–7,274,869 | 872 bp | At TSS Multiome | 312 | |
| chrY:7,279,970–7,280,660 | 5.1 kb | Proximal (<10kb) | 26 | |
| chrY:7,451,837–7,452,942 | 177.6 kb | Distal (>10kb) Multiome | 163 |
Genomic view of the ENSG00000289826 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.