Transcription factors with Perturb-seq knockdown data for ENSG00000289626. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289626 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289626, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:68,788,943–68,789,202 | 6.0 kb | Proximal (<10kb) | 369 | |
| chr14:68,790,871–68,793,970 | 1.3 kb | Proximal (<10kb) | 866 | |
| chr14:68,794,111–68,794,734 | 515 bp | At TSS | 674 | |
| chr14:68,794,853–68,797,758 | at TSS | At TSS | 1023 |
Genomic view of the ENSG00000289626 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.