Transcription factors with Perturb-seq knockdown data for ENSG00000289615. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289615 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289615, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:72,137,371–72,137,974 | 6.7 kb | Proximal (<10kb) | 324 | |
| chr2:72,142,925–72,143,870 | 779 bp | At TSS | 202 | |
| chr2:72,144,434–72,145,640 | at TSS | At TSS | 473 | |
| chr2:72,147,066–72,147,950 | 2.4 kb | Proximal (<10kb) | 206 | |
| chr2:72,148,947–72,149,709 | 4.3 kb | Proximal (<10kb) | 267 | |
| chr2:72,149,850–72,150,987 | 5.2 kb | Proximal (<10kb) | 364 |
Genomic view of the ENSG00000289615 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.