Transcription factors with Perturb-seq knockdown data for ENSG00000289612. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289612 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289612, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:107,056,354–107,058,025 | 83.5 kb | Distal (>10kb) Multiome | 911 | |
| chr1:107,135,569–107,135,728 | 4.5 kb | Proximal (<10kb) | 131 | |
| chr1:107,139,482–107,140,719 | 197 bp | At TSS Multiome | 373 | |
| chr1:107,140,823–107,142,140 | 589 bp | At TSS | 465 | |
| chr1:107,142,245–107,142,405 | 2.0 kb | Proximal (<10kb) | 118 |
Genomic view of the ENSG00000289612 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.