Transcription factors with Perturb-seq knockdown data for ENSG00000289586. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289586 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289586, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:76,689,137–76,689,934 | 260.2 kb | Distal (>10kb) Multiome | 423 | |
| chr4:76,867,647–76,869,012 | 81.3 kb | Distal (>10kb) Multiome | 115 | |
| chr4:76,896,697–76,898,709 | 51.4 kb | Distal (>10kb) Multiome | 498 | |
| chr4:76,948,267–76,951,238 | 29 bp | At TSS Multiome | 968 | |
| chr4:77,074,968–77,076,780 | 125.8 kb | Distal (>10kb) Multiome | 1071 | |
| chr4:77,156,523–77,158,721 | 207.2 kb | Distal (>10kb) Multiome | 1039 | |
| chr4:77,193,476–77,193,939 | 244.0 kb | Distal (>10kb) Multiome | 188 |
Genomic view of the ENSG00000289586 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.