Transcription factors with Perturb-seq knockdown data for ENSG00000289561. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289561 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289561, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:79,310,548–79,311,770 | 61.6 kb | Distal (>10kb) Multiome | 801 | |
| chr15:79,365,900–79,366,110 | 6.5 kb | Proximal (<10kb) | 41 | |
| chr15:79,370,754–79,371,061 | 1.5 kb | Proximal (<10kb) | 69 | |
| chr15:79,372,517–79,372,841 | at TSS | At TSS | 22 | |
| chr15:79,381,122–79,381,325 | 8.5 kb | Proximal (<10kb) | 149 | |
| chr15:79,431,580–79,432,877 | 59.7 kb | Distal (>10kb) Multiome | 335 |
Genomic view of the ENSG00000289561 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.