Transcription factors with Perturb-seq knockdown data for ENSG00000289550. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289550 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289550, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:12,271,329–12,272,193 | 7.0 kb | Proximal (<10kb) | 601 | |
| chr18:12,279,102–12,279,484 | at TSS | At TSS | 298 | |
| chr18:12,283,799–12,284,124 | 4.6 kb | Proximal (<10kb) | 78 | |
| chr18:12,287,265–12,288,653 | 8.1 kb | Proximal (<10kb) | 353 | |
| chr18:12,288,796–12,289,337 | 9.6 kb | Proximal (<10kb) | 159 |
Genomic view of the ENSG00000289550 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.