Transcription factors with Perturb-seq knockdown data for ENSG00000289533. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289533 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289533, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:67,322,668–67,322,938 | 8.9 kb | Proximal (<10kb) | 179 | |
| chr2:67,332,809–67,332,950 | 929 bp | At TSS | 3 | |
| chr2:67,333,049–67,333,584 | 1.2 kb | Proximal (<10kb) | 82 | |
| chr2:67,334,493–67,334,707 | 2.6 kb | Proximal (<10kb) | 6 | |
| chr2:67,335,809–67,336,264 | 3.9 kb | Proximal (<10kb) | 4 | |
| chr2:67,336,365–67,336,789 | 4.5 kb | Proximal (<10kb) | 7 | |
| chr2:67,397,100–67,398,169 | 65.5 kb | Distal (>10kb) Multiome | 810 |
Genomic view of the ENSG00000289533 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.