Transcription factors with Perturb-seq knockdown data for ENSG00000289478. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289478 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289478, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:141,674,753–141,675,190 | 7.1 kb | Proximal (<10kb) | 101 | |
| chr5:141,680,751–141,681,516 | 807 bp | At TSS | 257 | |
| chr5:141,681,692–141,682,621 | at TSS | At TSS | 554 | |
| chr5:141,687,103–141,687,289 | 4.8 kb | Proximal (<10kb) | 25 | |
| chr5:141,692,108–141,692,560 | 9.8 kb | Proximal (<10kb) | 498 |
Genomic view of the ENSG00000289478 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.