Transcription factors with Perturb-seq knockdown data for ENSG00000289463. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289463 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289463, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:71,129,728–71,130,863 | 289.6 kb | Distal (>10kb) Multiome | 1092 | |
| chr2:71,226,288–71,227,849 | 192.7 kb | Distal (>10kb) Multiome | 657 | |
| chr2:71,276,206–71,277,158 | 143.4 kb | Distal (>10kb) Multiome | 790 | |
| chr2:71,331,200–71,332,517 | 88.2 kb | Distal (>10kb) Multiome | 920 | |
| chr2:71,416,834–71,417,039 | 2.9 kb | Proximal (<10kb) | 16 | |
| chr2:71,453,379–71,454,558 | 33.8 kb | Distal (>10kb) Multiome | 298 | |
| chr2:71,466,113–71,467,114 | 46.8 kb | Distal (>10kb) Multiome | 334 |
Genomic view of the ENSG00000289463 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.