Transcription factors with Perturb-seq knockdown data for ENSG00000289441. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289441 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289441, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:101,282,747–101,283,297 | 602 bp | At TSS | 74 | |
| chr10:101,285,534–101,286,046 | 1.6 kb | Proximal (<10kb) | 150 | |
| chr10:101,288,327–101,289,007 | 4.4 kb | Proximal (<10kb) | 96 | |
| chr10:101,291,317–101,293,346 | 7.4 kb | Proximal (<10kb) | 433 |
Genomic view of the ENSG00000289441 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.