Transcription factors with Perturb-seq knockdown data for ENSG00000289419. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289419 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289419, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:147,504,803–147,505,299 | 103.2 kb | Distal (>10kb) Multiome | 199 | |
| chr1:147,540,743–147,542,280 | 66.9 kb | Distal (>10kb) Multiome | 562 | |
| chr1:147,598,654–147,600,842 | 8.4 kb | Proximal (<10kb) Multiome | 743 | |
| chr1:147,669,496–147,671,101 | 62.2 kb | Distal (>10kb) Multiome | 793 | |
| chr1:147,833,206–147,834,500 | 225.3 kb | Distal (>10kb) Multiome | 152 |
Genomic view of the ENSG00000289419 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.