Transcription factors with Perturb-seq knockdown data for ENSG00000289396. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289396 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289396, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:196,867,462–196,868,618 | 207.5 kb | Distal (>10kb) Multiome | 794 | |
| chr3:196,941,814–196,943,294 | 132.8 kb | Distal (>10kb) Multiome | 1027 | |
| chr3:196,968,365–196,969,147 | 106.6 kb | Distal (>10kb) Multiome | 597 | |
| chr3:196,969,208–196,970,172 | 105.3 kb | Distal (>10kb) Multiome | 714 | |
| chr3:197,002,398–197,004,003 | 72.2 kb | Distal (>10kb) Multiome | 569 | |
| chr3:197,028,743–197,030,204 | 45.5 kb | Distal (>10kb) Multiome | 646 | |
| chr3:197,297,490–197,299,437 | 223.0 kb | Distal (>10kb) Multiome | 941 |
Genomic view of the ENSG00000289396 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.