Transcription factors with Perturb-seq knockdown data for ENSG00000289376. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289376 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289376, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:116,100,248–116,101,958 | 169 bp | At TSS Multiome | 1010 | |
| chr6:116,106,708–116,107,233 | 6.0 kb | Proximal (<10kb) | 216 | |
| chr6:116,110,364–116,110,682 | 9.7 kb | Proximal (<10kb) | 9 | |
| chr6:116,229,156–116,229,872 | 128.8 kb | Distal (>10kb) Multiome | 151 | |
| chr6:116,253,243–116,254,510 | 153.3 kb | Distal (>10kb) Multiome | 816 | |
| chr6:116,279,028–116,280,325 | 179.1 kb | Distal (>10kb) Multiome | 994 | |
| chr6:116,370,005–116,371,990 | 271.0 kb | Distal (>10kb) Multiome | 655 |
Genomic view of the ENSG00000289376 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.