Transcription factors with Perturb-seq knockdown data for ENSG00000289305. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289305 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289305, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:233,326,831–233,329,042 | 286.0 kb | Distal (>10kb) Multiome | 601 | |
| chr1:233,471,138–233,474,579 | 141.7 kb | Distal (>10kb) Multiome HiCAR | 432 | |
| chr1:233,587,899–233,588,712 | 25.2 kb | Distal (>10kb) Multiome | 287 | |
| chr1:233,613,392–233,615,436 | 347 bp | At TSS Multiome | 660 | |
| chr1:233,635,902–233,636,667 | 22.7 kb | Distal (>10kb) Multiome | 637 | |
| chr1:233,904,279–233,905,767 | 291.2 kb | Distal (>10kb) Multiome | 438 |
Genomic view of the ENSG00000289305 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.