Transcription factors with Perturb-seq knockdown data for ENSG00000289294. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289294 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289294, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:203,014,312–203,015,568 | 224.5 kb | Distal (>10kb) Multiome | 901 | |
| chr2:203,238,491–203,240,168 | 211 bp | At TSS Multiome | 1095 | |
| chr2:203,327,637–203,329,261 | 88.9 kb | Distal (>10kb) Multiome | 970 | |
| chr2:203,534,668–203,535,941 | 296.1 kb | Distal (>10kb) Multiome | 813 |
Genomic view of the ENSG00000289294 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.