Transcription factors with Perturb-seq knockdown data for ENSG00000289289. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289289 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289289, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:34,795,012–34,796,020 | 266.7 kb | Distal (>10kb) Multiome | 219 | |
| chr15:34,969,126–34,970,219 | 92.3 kb | Distal (>10kb) Multiome | 886 | |
| chr15:34,987,975–34,988,845 | 73.8 kb | Distal (>10kb) Multiome | 940 | |
| chr15:35,018,915–35,019,739 | 42.8 kb | Distal (>10kb) Multiome | 105 | |
| chr15:35,019,863–35,020,882 | 41.6 kb | Distal (>10kb) Multiome | 129 | |
| chr15:35,060,049–35,060,361 | 1.8 kb | Proximal (<10kb) | 18 | |
| chr15:35,061,561–35,061,738 | 425 bp | At TSS | 18 |
Genomic view of the ENSG00000289289 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.