Transcription factors with Perturb-seq knockdown data for ENSG00000289277. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289277 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289277, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:44,194,373–44,195,992 | 92.9 kb | Distal (>10kb) Multiome | 633 | |
| chr15:44,287,925–44,288,439 | at TSS | At TSS | 598 | |
| chr15:44,288,537–44,289,473 | 482 bp | At TSS Multiome | 806 | |
| chr15:44,426,579–44,428,620 | 138.9 kb | Distal (>10kb) Multiome | 941 | |
| chr15:44,536,026–44,537,829 | 248.7 kb | Distal (>10kb) Multiome | 958 |
Genomic view of the ENSG00000289277 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.